CMap Candidate Details

Structure:
CMap ID: C25995
Pert ID: BRD-K74148702
Compound Name: curcumin
Targets: PTGS1; PTGS2
MoA: Cyclooxygenase inhibitor; Lipoxygenase inhibitor; NFKB pathway inhibitor; Histone acetyltransferase inhibitor
SMILES: COc1ccc(/C=C/C(=O)CC(=O)C=Cc2cccc(O)c2OC)cc1O
InchiKey: VZMSCIKIANDZNI-OAMUUVBCSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9064 BRD-K74148702 A375 50 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9229 BRD-K74148702 A549 50 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9499 BRD-K74148702 AGS 50 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9803 BRD-K74148702 H1299 50 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10078 BRD-K74148702 HA1E 50 uM 6 h 0.0 0.0 0.0 0.29 1.02 0.48
10367 BRD-K74148702 HCC515 50 uM 6 h 0.0 0.0 0.0 0.33 1.16 0.9
10585 BRD-K74148702 HCT116 50 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10842 BRD-K74148702 HEPG2 50 uM 6 h -0.21 -0.87 0.02 0.26 0.91 0.23
11118 BRD-K74148702 HT29 50 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11295 BRD-K74148702 MCF??7.00 50 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11566 BRD-K74148702 NCIH2073 50 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11830 BRD-K74148702 NCIH508 50 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12123 BRD-K74148702 NCIH596 50 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12375 BRD-K74148702 NOMO1 50 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12625 BRD-K74148702 PC3 50 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12860 BRD-K74148702 SW480 50 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13111 BRD-K74148702 THP1 50 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13350 BRD-K74148702 U937 50 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13501 BRD-K74148702 VCAP 50 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95932 BRD-K74148702 YAPC 1.11 uM 6 h 0.0 0.0 0.0 -0.35 -1.16 1.11
99082 BRD-K74148702 NEU 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
99250 BRD-K74148702 NPC 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).