CMap Candidate Details

Structure:
CMap ID: C26174
Pert ID: BRD-K74717603
Compound Name: etravirine
Targets: CYP2C19; CYP2C9; CYP3A4
MoA: Non-nucleoside reverse transcriptase inhibitor
SMILES: Cc1cc(cc(C)c1Oc1nc(Nc2ccc(cc2)C#N)nc(N)c1Br)C#N
InchiKey: PYGWGZALEOIKDF-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127357 BRD-K74717603 A375 10 uM 24 h 0.0 0.0 0.0 -0.43 -1.46 15.35
127431 BRD-K74717603 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127469 BRD-K74717603 HELA 10 uM 24 h 0.0 0.0 0.0 -0.44 -1.48 15.35
127522 BRD-K74717603 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127559 BRD-K74717603 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127612 BRD-K74717603 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
127650 BRD-K74717603 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127692 BRD-K74717603 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135347 BRD-K74717603 A549 0.74 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.4
135408 BRD-K74717603 HT29 2.22 uM 24 h -0.28 -1.16 0.46 -0.3 -1.01 0.57
135474 BRD-K74717603 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).