CMap Candidate Details

Structure:
CMap ID: C26186
Pert ID: BRD-K74761218
Compound Name: WT-171
Targets: HDAC6
MoA: HDAC inhibitor
SMILES: ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(cc1)N(c2ccccc2)c3ccccc3
InchiKey: KXWWYFKVBFUVIZ-SGWCAAJKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25657 BRD-K74761218 A375 10 uM 6 h -0.19 -0.79 0.0 0.26 0.93 0.28
25987 BRD-K74761218 A549 10 uM 24 h -0.23 -0.96 0.09 0.0 0.0 0.0
26453 BRD-K74761218 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
26776 BRD-K74761218 HA1E 10 uM 6 h -0.2 -0.84 0.01 0.0 0.0 0.0
27077 BRD-K74761218 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
27389 BRD-K74761218 HT29 10 uM 6 h -0.18 -0.76 0.0 0.27 0.96 0.33
27606 BRD-K74761218 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
28020 BRD-K74761218 NEU 10 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.33
28335 BRD-K74761218 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
28522 BRD-K74761218 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
28969 BRD-K74761218 PHH 10 uM 24 h 0.0 0.0 0.0 0.25 0.87 0.17
29304 BRD-K74761218 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
29533 BRD-K74761218 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.2 -0.66 0.01
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).