CMap Candidate Details

Structure:
CMap ID: C26187
Pert ID: BRD-K74763371
Compound Name: bosentan
Targets: EDNRA; EDNRB
MoA: Endothelin receptor antagonist
SMILES: COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(nc1OCCO)-c1ncccn1
InchiKey: GJPICJJJRGTNOD-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
51177 BRD-K74763371 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91452 BRD-K74763371 HUH7 6.66 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
127013 BRD-K74763371 A375 3.33 uM 24 h -0.26 -1.09 0.31 0.0 0.0 0.0
127093 BRD-K74763371 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127131 BRD-K74763371 HT29 3.33 uM 24 h -0.17 -0.71 0.0 0.33 1.16 0.9
127205 BRD-K74763371 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.26
127232 BRD-K74763371 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127307 BRD-K74763371 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135035 BRD-K74763371 A549 0.01 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.54
135078 BRD-K74763371 HA1E 0.01 uM 24 h 0.25 1.05 0.16 0.0 0.0 0.0
135101 BRD-K74763371 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.2 0.71 0.02
135165 BRD-K74763371 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 -0.48 -1.6 15.65
135200 BRD-K74763371 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135254 BRD-K74763371 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.33
135303 BRD-K74763371 THP1 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).