CMap Candidate Details

Structure:
CMap ID: C02622
Pert ID: BRD-K00674894
Compound Name: orteronel
Targets: CYP17A1
MoA: Cytochrome P450 inhibitor; Androgen receptor antagonist; Androgen biosynthesis inhibitor
SMILES: CNC(=O)c1ccc2cc(ccc2c1)[C@]1(O)CCn2cncc12
InchiKey: OZPFIJIOIVJZMN-GOSISDBHSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
122855 BRD-K00674894 HA1E 10 uM 24 h 0.17 0.7 0.0 -0.3 -1.01 0.57
122884 BRD-K00674894 HEK293 10 uM 24 h 0.24 1.0 0.1 -0.2 -0.67 0.01
122934 BRD-K00674894 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122965 BRD-K00674894 HT29 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123009 BRD-K00674894 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123098 BRD-K00674894 MDAMB231 10 uM 24 h 0.23 0.97 0.08 0.0 0.0 0.0
123170 BRD-K00674894 THP1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131203 BRD-K00674894 A375 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131235 BRD-K00674894 A549 0.25 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.48
131346 BRD-K00674894 HUVEC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131393 BRD-K00674894 MCF10A 2.22 uM 24 h 0.21 0.88 0.02 0.22 0.78 0.06
131428 BRD-K00674894 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
131456 BRD-K00674894 PC3 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131487 BRD-K00674894 YAPC 0.25 uM 24 h 0.27 1.11 0.26 -0.25 -0.84 0.18
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).