CMap Candidate Details

Structure:
CMap ID: C26351
Pert ID: BRD-K75295174
Compound Name: alisertib
Targets: AURKA
MoA: Aurora kinase inhibitor
SMILES: COc1cc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2OC)ccc1C(O)=O
InchiKey: ZLHFILGSQDJULK-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
84313 BRD-K75295174 A549 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
85023 BRD-K75295174 A375 10 uM 24 h -0.24 -0.99 0.14 -0.36 -1.21 1.24
85428 BRD-K75295174 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
86098 BRD-K75295174 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
95706 BRD-K75295174 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95994 BRD-K75295174 PHH 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116880 BRD-K75295174 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119608 BRD-K75295174 MCF??7.00 3.33 uM 24 h 0.29 1.22 0.48 -0.43 -1.46 15.35
127064 BRD-K75295174 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.36
127096 BRD-K75295174 HELA 10 uM 24 h 0.0 0.0 0.0 0.23 0.83 0.11
127236 BRD-K75295174 PC3 3.33 uM 24 h 0.0 0.0 0.0 -0.47 -1.58 15.65
127279 BRD-K75295174 THP1 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127310 BRD-K75295174 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135083 BRD-K75295174 HA1E 0.74 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
135168 BRD-K75295174 JURKAT 2.22 uM 24 h 0.25 1.05 0.17 -0.29 -0.97 0.47
135204 BRD-K75295174 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135260 BRD-K75295174 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).