CMap Candidate Details

Structure:
CMap ID: C26455
Pert ID: BRD-K75641298
Compound Name: metoclopramide
Targets: DRD2; HTR3A; HTR4
MoA: Dopamine receptor antagonist; Serotonin receptor antagonist
SMILES: CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
InchiKey: TTWJBBZEZQICBI-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2920 BRD-K75641298 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.79
3257 BRD-K75641298 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3857 BRD-K75641298 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44617 BRD-K75641298 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45024 BRD-K75641298 ASC 10 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.24
45316 BRD-K75641298 HEPG2 10 uM 6 h 0.3 1.25 0.54 -0.22 -0.73 0.05
46137 BRD-K75641298 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46453 BRD-K75641298 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46778 BRD-K75641298 SKB 10 uM 24 h -0.26 -1.1 0.34 0.0 0.0 0.0
91020 BRD-K75641298 HUH7 12 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
96321 BRD-K75641298 A375 3.33 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.94
99467 BRD-K75641298 U2OS 10 uM 6 h 0.25 1.04 0.15 0.0 0.0 0.0
127470 BRD-K75641298 HELA 0.04 uM 24 h 0.2 0.82 0.0 0.32 1.14 0.87
127524 BRD-K75641298 JURKAT 0.37 uM 24 h 0.24 0.99 0.1 0.0 0.0 0.0
127614 BRD-K75641298 PC3 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.44
127694 BRD-K75641298 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135410 BRD-K75641298 HT29 0.25 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.57
135442 BRD-K75641298 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 0.41 1.44 2.21
135475 BRD-K75641298 MCF??7.00 2.22 uM 24 h -0.19 -0.77 0.0 0.35 1.23 1.22
135502 BRD-K75641298 THP1 0.74 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.16
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).