CMap Candidate Details

Structure:
CMap ID: C26557
Pert ID: BRD-K75958547
Compound Name: pitavastatin
Targets: HMGCR
MoA: HMGCR inhibitor
SMILES: O[C@H](C[C@H](O)C=Cc1c(nc2ccccc2c1-c1ccc(F)cc1)C1CC1)CC(O)=O
InchiKey: VGYFMXBACGZSIL-MCBHFWOFSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126352 BRD-K75958547 A375 1.11 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.29
126413 BRD-K75958547 HEK293 0.04 uM 24 h -0.24 -1.01 0.17 0.0 0.0 0.0
126463 BRD-K75958547 HELA 10 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.59
126486 BRD-K75958547 HT29 10 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
126545 BRD-K75958547 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.72
134366 BRD-K75958547 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134385 BRD-K75958547 HA1E 0.25 uM 24 h 0.0 0.0 0.0 0.25 0.88 0.18
134480 BRD-K75958547 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.97
134530 BRD-K75958547 MCF10A 2.22 uM 24 h -0.28 -1.15 0.44 0.35 1.23 1.19
134556 BRD-K75958547 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134613 BRD-K75958547 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134640 BRD-K75958547 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.31 1.08 0.66
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).