CMap Candidate Details

Structure:
CMap ID: C26789
Pert ID: BRD-K76617868
Compound Name: fasudil
Targets: ROCK1; ROCK2
MoA: Rho associated kinase inhibitor
SMILES: O=S(=O)(N1CCCNCC1)c1cccc2cnccc12
InchiKey: NGOGFTYYXHNFQH-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3859 BRD-K76617868 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45027 BRD-K76617868 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45846 BRD-K76617868 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
46140 BRD-K76617868 NPC 10 uM 24 h 0.27 1.13 0.28 0.0 0.0 0.0
46456 BRD-K76617868 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46780 BRD-K76617868 SKB 10 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.78
90998 BRD-K76617868 HUH7 12 uM 72 h -0.29 -1.21 0.58 -0.37 -1.23 1.28
97291 BRD-K76617868 HAP1 3.33 uM 24 h 0.0 0.0 0.0 -0.3 -0.99 0.51
99481 BRD-K76617868 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
116660 BRD-K76617868 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116742 BRD-K76617868 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116788 BRD-K76617868 HCC515 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116832 BRD-K76617868 HEPG2 10 uM 24 h 0.33 1.37 0.97 0.0 0.0 0.0
116877 BRD-K76617868 HT29 10 uM 24 h -0.24 -1.01 0.16 0.27 0.96 0.33
116966 BRD-K76617868 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127529 BRD-K76617868 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.78
127656 BRD-K76617868 THP1 10 uM 24 h -0.28 -1.17 0.5 0.29 1.02 0.46
127701 BRD-K76617868 YAPC 3.33 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.06
135349 BRD-K76617868 A549 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135376 BRD-K76617868 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.97
135445 BRD-K76617868 MCF10A 2.22 uM 24 h 0.22 0.91 0.03 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).