CMap Candidate Details

Structure:
CMap ID: C26821
Pert ID: BRD-K76694128
Compound Name: rebastinib
Targets: FLT3; ABL1; KDR; BCR; TEK
MoA: VEGFR inhibitor; Abl kinase inhibitor; TIE tyrosine kinase inhibitor
SMILES: CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc4ncccc4c3)C(C)(C)C)c(F)c2)ccn1
InchiKey: WVXNSAVVKYZVOE-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
92870 BRD-K76694128 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92897 BRD-K76694128 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92937 BRD-K76694128 ASC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93000 BRD-K76694128 CD34 10 uM 24 h 0.27 1.11 0.25 0.0 0.0 0.0
93043 BRD-K76694128 HA1E 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93088 BRD-K76694128 HEK293 10 uM 24 h -0.17 -0.72 0.0 0.37 1.31 1.59
93130 BRD-K76694128 HELA 10 uM 24 h 0.19 0.81 0.0 0.27 0.94 0.29
93173 BRD-K76694128 HEPG2 1.11 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
93226 BRD-K76694128 HUVEC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93280 BRD-K76694128 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.54
93318 BRD-K76694128 MCF10A 10 uM 24 h -0.24 -0.99 0.14 0.0 0.0 0.0
93361 BRD-K76694128 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93398 BRD-K76694128 NPC 3.33 uM 24 h 0.0 0.0 0.0 0.32 1.15 0.88
93447 BRD-K76694128 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93512 BRD-K76694128 SKL 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93546 BRD-K76694128 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93586 BRD-K76694128 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.68
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).