CMap Candidate Details

Structure:
CMap ID: C26833
Pert ID: BRD-K76723084
Compound Name: isotretinoin
Targets: RARA; RARB; RARG
MoA: Retinoid receptor agonist
SMILES: CC(/C=C/C1=C(C)CCCC1(C)C)=CC=CC(C)=C/C(O)=O
InchiKey: SHGAZHPCJJPHSC-XFYACQKRSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33561 BRD-K76723084 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
33838 BRD-K76723084 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34174 BRD-K76723084 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34955 BRD-K76723084 HEPG2 10 uM 6 h -0.25 -1.03 0.2 0.0 0.0 0.0
36346 BRD-K76723084 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36642 BRD-K76723084 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
50235 BRD-K76723084 HA1E 10 uM 6 h 0.27 1.12 0.28 0.0 0.0 0.0
50409 BRD-K76723084 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50585 BRD-K76723084 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50685 BRD-K76723084 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
50950 BRD-K76723084 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
51064 BRD-K76723084 VCAP 10 uM 24 h 0.2 0.83 0.0 0.0 0.0 0.0
98770 BRD-K76723084 NPC 10 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.33
98933 BRD-K76723084 NEU 10 uM 24 h 0.18 0.77 0.0 0.0 0.0 0.0
99483 BRD-K76723084 U2OS 1.11 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).