CMap Candidate Details

Structure:
CMap ID: C26862
Pert ID: BRD-K76812510
Compound Name: metamizole
Targets: PTGS1
MoA: Opioid receptor agonist; Cyclooxygenase inhibitor
SMILES: CN(CS(O)(=O)=O)c1c(C)n(C)n(-c2ccccc2)c1=O
InchiKey: LVWZTYCIRDMTEY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
99487 BRD-K76812510 U2OS 6.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
127073 BRD-K76812510 HEK293 0.04 uM 24 h 0.24 1.02 0.12 -0.24 -0.82 0.15
127247 BRD-K76812510 PC3 0.125 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.6
127285 BRD-K76812510 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135018 BRD-K76812510 A375 2.22 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
135050 BRD-K76812510 A549 0.03 uM 24 h -0.23 -0.97 0.1 0.19 0.66 0.01
135088 BRD-K76812510 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135132 BRD-K76812510 HELA 0.25 uM 24 h -0.24 -0.98 0.12 0.2 0.71 0.02
135150 BRD-K76812510 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135178 BRD-K76812510 JURKAT 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135211 BRD-K76812510 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.64
135234 BRD-K76812510 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135274 BRD-K76812510 MDAMB231 0.01 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.86
135329 BRD-K76812510 YAPC 2.22 uM 24 h 0.29 1.2 0.43 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).