CMap Candidate Details

Structure:
CMap ID: C26871
Pert ID: BRD-K76841105
Compound Name: tazarotene
Targets: RARA; RARB; RARG
MoA: Retinoid receptor agonist
SMILES: CCOC(=O)c1ccc(nc1)C#Cc1ccc2SCCC(C)(C)c2c1
InchiKey: OGQICQVSFDPSEI-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
96632 BRD-K76841105 A375 3.33 uM 24 h -0.21 -0.89 0.03 0.0 0.0 0.0
127046 BRD-K76841105 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127104 BRD-K76841105 HELA 1.11 uM 24 h -0.19 -0.8 0.0 0.0 0.0 0.0
127186 BRD-K76841105 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127244 BRD-K76841105 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127319 BRD-K76841105 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135047 BRD-K76841105 A549 2.22 uM 24 h 0.27 1.12 0.26 0.0 0.0 0.0
135110 BRD-K76841105 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135149 BRD-K76841105 HT29 0.08 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.69
135176 BRD-K76841105 JURKAT 0.74 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
135231 BRD-K76841105 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.51
135271 BRD-K76841105 MDAMB231 0.74 uM 24 h 0.23 0.95 0.06 0.0 0.0 0.0
135310 BRD-K76841105 THP1 0.74 uM 24 h -0.26 -1.07 0.28 -0.28 -0.93 0.35
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).