CMap Candidate Details

Structure:
CMap ID: C02688
Pert ID: BRD-K00911143
Compound Name: brexpiprazole
Targets: DRD2; HTR1A; HTR2A
MoA: Dopamine receptor partial agonist
SMILES: O=c1ccc2ccc(OCCCCN3CCN(CC3)c3cccc4sccc34)cc2[nH]1
InchiKey: ZKIAIYBUSXZPLP-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
122857 BRD-K00911143 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122888 BRD-K00911143 HEK293 1.11 uM 24 h -0.23 -0.97 0.11 -0.38 -1.27 1.43
122936 BRD-K00911143 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122968 BRD-K00911143 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123013 BRD-K00911143 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123059 BRD-K00911143 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
123073 BRD-K00911143 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.48
123102 BRD-K00911143 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.7
123144 BRD-K00911143 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123174 BRD-K00911143 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123215 BRD-K00911143 YAPC 10 uM 24 h 0.2 0.83 0.0 0.28 0.99 0.39
131206 BRD-K00911143 A375 0.01 uM 24 h -0.28 -1.18 0.51 0.0 0.0 0.0
131239 BRD-K00911143 A549 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131350 BRD-K00911143 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).