CMap Candidate Details

Structure:
CMap ID: C26920
Pert ID: BRD-K76953762
Compound Name: indoramin
Targets: ADRA1D; ADRA1A
MoA: Adrenergic receptor antagonist
SMILES: O=C(NC1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccccc1
InchiKey: JXZZEXZZKAWDSP-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127023 BRD-K76953762 A375 3.33 uM 24 h -0.29 -1.21 0.6 0.29 1.02 0.49
127047 BRD-K76953762 HA1E 0.04 uM 24 h 0.21 0.88 0.02 0.0 0.0 0.0
127071 BRD-K76953762 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127105 BRD-K76953762 HELA 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127141 BRD-K76953762 HT29 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 1.0
127166 BRD-K76953762 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
127245 BRD-K76953762 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127284 BRD-K76953762 THP1 0.125 uM 24 h 0.21 0.87 0.01 -0.17 -0.57 0.0
127320 BRD-K76953762 YAPC 0.04 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.55
135048 BRD-K76953762 A549 0.03 uM 24 h -0.25 -1.03 0.2 0.26 0.93 0.26
135209 BRD-K76953762 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 -0.37 -1.23 1.28
135232 BRD-K76953762 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135272 BRD-K76953762 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).