CMap Candidate Details

Structure:
CMap ID: C26925
Pert ID: BRD-K76964878
Compound Name: EX-527
Targets: SIRT1
MoA: SIRT inhibitor
SMILES: NC(=O)[C@H]1CCCc2c1[nH]c1ccc(Cl)cc21
InchiKey: FUZYTVDVLBBXDL-VIFPVBQESA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8984 BRD-K76964878 A375 25 uM 24 h 0.0 0.0 0.0 -0.25 -0.86 0.2
9506 BRD-K76964878 AGS 25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9810 BRD-K76964878 H1299 25 uM 6 h 0.0 0.0 0.0 0.21 0.74 0.03
10081 BRD-K76964878 HA1E 25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11837 BRD-K76964878 NCIH508 25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12129 BRD-K76964878 NCIH596 25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12380 BRD-K76964878 NOMO1 25 uM 6 h 0.31 1.27 0.59 0.0 0.0 0.0
12510 BRD-K76964878 PC3 25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
12867 BRD-K76964878 SW480 25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13358 BRD-K76964878 U937 25 uM 6 h 0.0 0.0 0.0 -0.29 -0.98 0.48
13679 BRD-K76964878 VCAP 25 uM 6 h -0.18 -0.76 0.0 0.0 0.0 0.0
93681 BRD-K76964878 ASC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93700 BRD-K76964878 CD34 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93785 BRD-K76964878 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93828 BRD-K76964878 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93876 BRD-K76964878 HELA 10 uM 24 h 0.25 1.04 0.15 -0.45 -1.52 15.35
93917 BRD-K76964878 HEPG2 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93984 BRD-K76964878 HUVEC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94013 BRD-K76964878 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.22 0.78 0.07
94092 BRD-K76964878 NEU 10 uM 24 h -0.25 -1.03 0.19 -0.29 -0.97 0.45
94171 BRD-K76964878 NPC 1.11 uM 24 h 0.23 0.97 0.08 0.0 0.0 0.0
94225 BRD-K76964878 SHSY5Y 10 uM 24 h -0.2 -0.83 0.0 0.0 0.0 0.0
94276 BRD-K76964878 SKL 3.33 uM 24 h 0.0 0.0 0.0 -0.17 -0.58 0.0
94327 BRD-K76964878 THP1 1.11 uM 24 h 0.23 0.97 0.08 0.31 1.08 0.65
94371 BRD-K76964878 YAPC 0.12 uM 24 h 0.0 0.0 0.0 -0.22 -0.73 0.05
95781 BRD-K76964878 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
117566 BRD-K76964878 HT29 3.33 uM 24 h 0.0 0.0 0.0 -0.31 -1.06 0.72
117604 BRD-K76964878 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).