CMap Candidate Details

Structure:
CMap ID: C26946
Pert ID: BRD-K77008974
Compound Name: WYE-354
Targets: MTOR
MoA: MTOR inhibitor
SMILES: COC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)OC)c2n1
InchiKey: IMXHGCRIEAKIBU-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33708 BRD-K77008974 A375 10 uM 6 h 0.18 0.76 0.0 -0.19 -0.63 0.01
33927 BRD-K77008974 A549 10 uM 6 h -0.29 -1.21 0.59 0.0 0.0 0.0
34175 BRD-K77008974 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34417 BRD-K77008974 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.96 0.42
34681 BRD-K77008974 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.16 -0.54 0.0
34956 BRD-K77008974 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.34 -1.14 1.02
35198 BRD-K77008974 HT29 10 uM 6 h -0.24 -0.99 0.13 0.0 0.0 0.0
35344 BRD-K77008974 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.86 0.21
35617 BRD-K77008974 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35837 BRD-K77008974 NPC 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.87
36101 BRD-K77008974 PC3 10 uM 6 h 0.0 0.0 0.0 -0.23 -0.78 0.1
36643 BRD-K77008974 SKB 10 uM 24 h -0.33 -1.37 1.08 0.0 0.0 0.0
36866 BRD-K77008974 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.19 -0.63 0.01
95976 BRD-K77008974 PHH 3.33 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.15
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).