CMap Candidate Details

Structure:
CMap ID: C27019
Pert ID: BRD-K77286328
Compound Name: reversine
Targets: AURKB
MoA: Aurora kinase inhibitor
SMILES: C1CCC(CC1)Nc2nc(Nc3ccc(cc3)N4CCOCC4)nc5[nH]cnc25
InchiKey: ZFLJHSQHILSNCM-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33668 BRD-K77286328 A375 10 uM 6 h 0.25 1.06 0.19 0.39 1.37 1.98
33840 BRD-K77286328 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34176 BRD-K77286328 ASC 10 uM 24 h 0.0 0.0 0.0 0.19 0.67 0.01
34419 BRD-K77286328 HA1E 10 uM 6 h 0.0 0.0 0.0 0.28 0.98 0.38
34683 BRD-K77286328 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34958 BRD-K77286328 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35200 BRD-K77286328 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35346 BRD-K77286328 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.13
35618 BRD-K77286328 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35838 BRD-K77286328 NPC 10 uM 24 h 0.2 0.85 0.01 0.0 0.0 0.0
36102 BRD-K77286328 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36348 BRD-K77286328 PHH 10 uM 24 h 0.19 0.81 0.0 0.0 0.0 0.0
36645 BRD-K77286328 SKB 10 uM 24 h 0.0 0.0 0.0 -0.16 -0.52 0.0
36868 BRD-K77286328 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.15
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).