CMap Candidate Details

Structure:
CMap ID: C27095
Pert ID: BRD-K77561571
Compound Name: topiroxostat
Targets: XDH
MoA: Xanthine oxidase inhibitor
SMILES: N#Cc1cc(ccn1)-c1n[nH]c(n1)-c1ccncc1
InchiKey: UBVZQGOVTLIHLH-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127364 BRD-K77561571 A375 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127401 BRD-K77561571 A549 0.04 uM 24 h -0.26 -1.08 0.28 0.0 0.0 0.0
127440 BRD-K77561571 HA1E 1.11 uM 24 h -0.19 -0.78 0.0 -0.17 -0.58 0.0
127474 BRD-K77561571 HELA 0.125 uM 24 h -0.36 -1.48 1.43 0.23 0.81 0.08
127530 BRD-K77561571 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.37
127581 BRD-K77561571 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.31 1.08 0.66
127619 BRD-K77561571 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127657 BRD-K77561571 THP1 0.04 uM 24 h -0.2 -0.85 0.01 0.0 0.0 0.0
127703 BRD-K77561571 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135415 BRD-K77561571 HT29 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135447 BRD-K77561571 MCF10A 0.03 uM 24 h 0.32 1.32 0.82 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).