CMap Candidate Details

Structure:
CMap ID: C27113
Pert ID: BRD-K77625799
Compound Name: vandetanib
Targets: EGFR; FLT1; FLT4; KDR; PTK6; RET; TEK
MoA: EGFR inhibitor; VEGFR inhibitor; RET tyrosine kinase inhibitor
SMILES: COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
InchiKey: UHTHHESEBZOYNR-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1213 BRD-K77625799 PC3 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.17
1339 BRD-K77625799 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92883 BRD-K77625799 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92967 BRD-K77625799 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93024 BRD-K77625799 CD34 10 uM 24 h 0.34 1.42 1.08 0.0 0.0 0.0
93109 BRD-K77625799 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93192 BRD-K77625799 HEPG2 10 uM 24 h -0.23 -0.96 0.1 0.0 0.0 0.0
93250 BRD-K77625799 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93300 BRD-K77625799 JURKAT 10 uM 24 h 0.26 1.07 0.19 0.0 0.0 0.0
93378 BRD-K77625799 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.35 1.26 1.29
93434 BRD-K77625799 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93523 BRD-K77625799 SKL 10 uM 24 h -0.21 -0.87 0.02 0.34 1.21 1.15
117134 BRD-K77625799 HCC515 1.11 uM 24 h -0.28 -1.17 0.49 -0.27 -0.91 0.31
127400 BRD-K77625799 A549 3.33 uM 24 h -0.33 -1.36 1.06 0.36 1.28 1.37
127438 BRD-K77625799 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127473 BRD-K77625799 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127562 BRD-K77625799 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127580 BRD-K77625799 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.62
127655 BRD-K77625799 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127700 BRD-K77625799 YAPC 10 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.98
135414 BRD-K77625799 HT29 0.74 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.98
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).