CMap Candidate Details

Structure:
CMap ID: C27132
Pert ID: BRD-K77677632
Compound Name: SB-200646
Targets: HTR2B; HTR2C
MoA: Serotonin receptor antagonist
SMILES: Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc12
InchiKey: OJZZJTLBYXHUSJ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4142 BRD-K77677632 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4488 BRD-K77677632 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.86
4720 BRD-K77677632 PC3 10 uM 24 h -0.17 -0.72 0.0 0.28 0.99 0.39
4962 BRD-K77677632 VCAP 10 uM 24 h 0.21 0.86 0.01 0.38 1.34 1.72
39175 BRD-K77677632 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39488 BRD-K77677632 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40057 BRD-K77677632 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40321 BRD-K77677632 HT29 10 uM 6 h -0.27 -1.14 0.42 -0.46 -1.56 15.65
40504 BRD-K77677632 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.21 0.73 0.03
40865 BRD-K77677632 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41182 BRD-K77677632 NPC 10 uM 24 h 0.3 1.26 0.56 0.0 0.0 0.0
41521 BRD-K77677632 SKB 10 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.13
99498 BRD-K77677632 U2OS 10 uM 6 h 0.28 1.15 0.34 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).