CMap Candidate Details

Structure:
CMap ID: C27169
Pert ID: BRD-K77793136
Compound Name: hydroxyfasudil
Targets: ROCK1
MoA: Rho associated kinase inhibitor
SMILES: Oc1nccc2c(cccc12)S(=O)(=O)N1CCCNCC1
InchiKey: ZAVGJDAFCZAWSZ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
7024 BRD-K77793136 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7481 BRD-K77793136 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7712 BRD-K77793136 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7911 BRD-K77793136 HT29 10 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.05
8284 BRD-K77793136 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.18 -0.61 0.0
8844 BRD-K77793136 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.9 0.29
96980 BRD-K77793136 A375 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.93
97059 BRD-K77793136 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).