CMap Candidate Details

Structure:
CMap ID: C27216
Pert ID: BRD-K77908580
Compound Name: entinostat
Targets: HDAC1
MoA: HDAC inhibitor
SMILES: Nc1ccccc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1
InchiKey: INVTYAOGFAGBOE-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1464 BRD-K77908580 NPC 0.66 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.63
30553 BRD-K77908580 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
31606 BRD-K77908580 HT29 10 uM 6 h 0.0 0.0 0.0 0.26 0.91 0.24
32238 BRD-K77908580 NEU 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.28 1.45
32833 BRD-K77908580 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
33137 BRD-K77908580 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33929 BRD-K77908580 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34961 BRD-K77908580 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36351 BRD-K77908580 PHH 10 uM 24 h -0.21 -0.88 0.03 -0.31 -1.06 0.73
36870 BRD-K77908580 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93713 BRD-K77908580 CD34 10 uM 24 h 0.25 1.03 0.13 0.0 0.0 0.0
93793 BRD-K77908580 HCC515 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93840 BRD-K77908580 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93961 BRD-K77908580 HUVEC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94024 BRD-K77908580 JURKAT 10 uM 24 h 0.17 0.7 0.0 0.0 0.0 0.0
94288 BRD-K77908580 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94337 BRD-K77908580 THP1 1.11 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
95622 BRD-K77908580 U2OS 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97257 BRD-K77908580 HAP1 0.66 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.24
97936 BRD-K77908580 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97964 BRD-K77908580 P1A82 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119413 BRD-K77908580 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126394 BRD-K77908580 HA1E 0.37 uM 24 h 0.21 0.89 0.02 -0.41 -1.38 2.02
126505 BRD-K77908580 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134416 BRD-K77908580 HELA 0.74 uM 24 h 0.0 0.0 0.0 -0.23 -0.76 0.07
134583 BRD-K77908580 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134641 BRD-K77908580 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136398 BRD-K77908580 SHSY5Y 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).