CMap Candidate Details

Structure:
CMap ID: C27254
Pert ID: BRD-K78010432
Compound Name: furosemide
Targets: SLC12A1; SLC12A2
MoA: Diuretic
SMILES: NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl
InchiKey: ZZUFCTLCJUWOSV-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90805 BRD-K78010432 HPTEC 1000 uM 6 h 0.0 0.0 0.0 -0.2 -0.66 0.01
91390 BRD-K78010432 HUH7 10 uM 72 h 0.25 1.04 0.14 0.0 0.0 0.0
99503 BRD-K78010432 U2OS 10 uM 6 h 0.18 0.74 0.0 0.0 0.0 0.0
127026 BRD-K78010432 A375 3.33 uM 24 h -0.24 -1.01 0.15 0.0 0.0 0.0
127109 BRD-K78010432 HELA 0.125 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
127145 BRD-K78010432 HT29 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127167 BRD-K78010432 JURKAT 0.125 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
127215 BRD-K78010432 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.44
127249 BRD-K78010432 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127322 BRD-K78010432 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135053 BRD-K78010432 A549 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135090 BRD-K78010432 HA1E 0.74 uM 24 h -0.2 -0.84 0.01 0.26 0.93 0.26
135111 BRD-K78010432 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135214 BRD-K78010432 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135277 BRD-K78010432 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135313 BRD-K78010432 THP1 0.03 uM 24 h -0.21 -0.89 0.03 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).