CMap Candidate Details

Structure:
CMap ID: C27427
Pert ID: BRD-K78599730
Compound Name: manumycin-a
Targets: FNTA; IKBKB
MoA: NFKB pathway inhibitor; Farnesyltransferase inhibitor
SMILES: CCCC[C@@H](C)/C=C(C)/C=C(C)/C(=O)NC1=C[C@@](O)(C=CC=CC=CC(=O)NC2C(=O)CCC2=O)[C@@H]3O[C@@H]3C1=O
InchiKey: XIZGHTZLVCHYJN-MVTGTTCWSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6799 BRD-K78599730 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7025 BRD-K78599730 A549 10 uM 24 h 0.19 0.81 0.0 0.33 1.16 0.9
7482 BRD-K78599730 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7713 BRD-K78599730 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
8024 BRD-K78599730 HT29 10 uM 6 h 0.0 0.0 0.0 -0.22 -0.73 0.04
8272 BRD-K78599730 MCF??7.00 10 uM 6 h 0.3 1.24 0.53 0.0 0.0 0.0
8406 BRD-K78599730 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8722 BRD-K78599730 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9510 BRD-K78599730 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9815 BRD-K78599730 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10597 BRD-K78599730 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10850 BRD-K78599730 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.04 0.67
11576 BRD-K78599730 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12134 BRD-K78599730 NCIH596 10 uM 6 h 0.24 0.99 0.1 0.0 0.0 0.0
12383 BRD-K78599730 NOMO1 10 uM 6 h 0.27 1.11 0.26 0.0 0.0 0.0
12871 BRD-K78599730 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
96234 BRD-K78599730 U2OS 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97246 BRD-K78599730 HAP1 3.33 uM 24 h 0.0 0.0 0.0 0.37 1.3 1.59
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).