CMap Candidate Details

Structure:
CMap ID: C02765
Pert ID: BRD-K01174345
Compound Name: anamorelin
Targets: GHSR
MoA: Growth hormone secretagogue receptor agonist
SMILES: CN(C)N(C)C(=O)[C@@]1(Cc2ccccc2)CCCN(C1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N
InchiKey: VQPFSIRUEPQQPP-MXBOTTGLSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
122887 BRD-K01174345 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122967 BRD-K01174345 HT29 10 uM 24 h 0.17 0.71 0.0 0.0 0.0 0.0
123012 BRD-K01174345 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123101 BRD-K01174345 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.14
123173 BRD-K01174345 THP1 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131205 BRD-K01174345 A375 0.25 uM 24 h -0.21 -0.86 0.02 -0.44 -1.5 15.35
131238 BRD-K01174345 A549 0.01 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.23
131275 BRD-K01174345 HA1E 0.25 uM 24 h -0.31 -1.28 0.76 0.0 0.0 0.0
131301 BRD-K01174345 HELA 0.25 uM 24 h 0.28 1.17 0.37 -0.27 -0.9 0.29
131349 BRD-K01174345 HUVEC 0.08 uM 24 h -0.21 -0.87 0.02 0.0 0.0 0.0
131394 BRD-K01174345 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131431 BRD-K01174345 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 -0.45 -1.52 15.35
131459 BRD-K01174345 PC3 0.01 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
131489 BRD-K01174345 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.35 1.23 1.19
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).