CMap Candidate Details

Structure:
CMap ID: C02769
Pert ID: BRD-K01188359
Compound Name: vinblastine
Targets: TUBB
MoA: Tubulin inhibitor; Microtubule inhibitor
SMILES: CC[C@]1(O)C[C@@H]2CN(C1)CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@@H]7[C@@]86CCN9CC=C[C@](CC)([C@H]98)[C@@H](OC(=O)C)[C@]7(O)C(=O)OC
InchiKey: JXLYSJRDGCGARV-CFWMRBGOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
53557 BRD-K01188359 HUH7 10 uM 6 h 0.0 0.0 0.0 -0.39 -1.31 1.7
53636 BRD-K01188359 PHH 2.5 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.15
117012 BRD-K01188359 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117048 BRD-K01188359 A549 0.04 uM 24 h -0.27 -1.12 0.38 0.0 0.0 0.0
117088 BRD-K01188359 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117129 BRD-K01188359 HCC515 10 uM 24 h -0.3 -1.26 0.72 0.0 0.0 0.0
117177 BRD-K01188359 HEPG2 1.11 uM 24 h 0.0 0.0 0.0 -0.35 -1.16 1.11
117223 BRD-K01188359 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117262 BRD-K01188359 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117297 BRD-K01188359 PC3 10 uM 24 h -0.24 -1.0 0.15 -0.29 -0.98 0.47
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).