CMap Candidate Details

Structure:
CMap ID: C00279
Pert ID: BRD-A10977446
Compound Name: carvedilol
Targets: ADRA1D; ADRA1B; ADRA1A; ADRB1; ADRB2; ADRB3
MoA: Adrenergic receptor antagonist
SMILES: COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12
InchiKey: OGHNVEJMJSYVRP-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5496 BRD-A10977446 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24980 BRD-A10977446 MCF??7.00 10 uM 24 h 0.33 1.39 1.01 0.28 0.99 0.41
25277 BRD-A10977446 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37441 BRD-A10977446 ASC 10 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
37783 BRD-A10977446 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37980 BRD-A10977446 HT29 10 uM 6 h 0.0 0.0 0.0 0.35 1.23 1.24
38819 BRD-A10977446 SKB 10 uM 24 h 0.19 0.79 0.0 0.0 0.0 0.0
52230 BRD-A10977446 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87987 BRD-A10977446 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90925 BRD-A10977446 HUH7 8 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
121167 BRD-A10977446 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121203 BRD-A10977446 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121238 BRD-A10977446 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121272 BRD-A10977446 HELA 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
129388 BRD-A10977446 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.22 0.78 0.07
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).