CMap Candidate Details

Structure:
CMap ID: C02795
Pert ID: BRD-K01253243
Compound Name: SB-590885
Targets: BRAF
MoA: RAF inhibitor
SMILES: CN(C)CCOc1ccc(cc1)-c1nc(c([nH]1)-c1ccc2c(CCC2=NO)c1)-c1ccncc1
InchiKey: MLSAQOINCGAULQ-QLTSDVKISA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33550 BRD-K01253243 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
33764 BRD-K01253243 A549 10 uM 24 h 0.23 0.97 0.08 0.0 0.0 0.0
34022 BRD-K01253243 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34299 BRD-K01253243 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34537 BRD-K01253243 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34805 BRD-K01253243 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35075 BRD-K01253243 HT29 10 uM 6 h 0.0 0.0 0.0 0.35 1.26 1.29
35921 BRD-K01253243 PC3 10 uM 24 h 0.27 1.11 0.25 0.0 0.0 0.0
36178 BRD-K01253243 PHH 10 uM 24 h 0.17 0.69 0.0 -0.24 -0.8 0.12
36472 BRD-K01253243 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36759 BRD-K01253243 VCAP 10 uM 24 h 0.21 0.88 0.01 -0.27 -0.89 0.27
90636 BRD-K01253243 HCT116 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90673 BRD-K01253243 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91501 BRD-K01253243 BT20 2.22 uM 24 h -0.22 -0.9 0.05 0.0 0.0 0.0
91568 BRD-K01253243 HS578T 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91680 BRD-K01253243 MDAMB231 10 uM 24 h 0.27 1.11 0.25 0.31 1.09 0.67
91747 BRD-K01253243 SKBR3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98028 BRD-K01253243 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.6
98078 BRD-K01253243 P1A82 10 uM 24 h 0.0 0.0 0.0 -0.42 -1.42 2.52
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).