CMap Candidate Details

Structure:
CMap ID: C00280
Pert ID: BRD-A11007541
Compound Name: BCI-hydrochloride
Targets: DUSP1; DUSP6
MoA: Protein phosphatase inhibitor
SMILES: O=C1c2ccccc2C(NC2CCCCC2)C1=Cc1ccccc1
InchiKey: XJDKPLZUXCIMIS-HKWRFOASSA-N
Compound Aliases: bci-hydrochloride

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33577 BRD-A11007541 A375 10 uM 6 h 0.0 0.0 0.0 -0.43 -1.46 15.35
33875 BRD-A11007541 A549 10 uM 6 h -0.2 -0.85 0.01 -0.37 -1.24 1.31
33971 BRD-A11007541 ASC 10 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.23
34254 BRD-A11007541 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34487 BRD-A11007541 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.38 -1.29 1.53
34759 BRD-A11007541 HEPG2 10 uM 6 h 0.23 0.96 0.08 -0.4 -1.36 2.02
35034 BRD-A11007541 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35398 BRD-A11007541 MCF??7.00 10 uM 6 h 0.24 1.01 0.12 -0.44 -1.48 15.35
35501 BRD-A11007541 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35901 BRD-A11007541 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36425 BRD-A11007541 SKB 10 uM 24 h -0.29 -1.2 0.55 0.0 0.0 0.0
36726 BRD-A11007541 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96015 BRD-A11007541 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).