CMap Candidate Details

Structure:
CMap ID: C28004
Pert ID: BRD-K80535353
Compound Name: enoxolone
Targets: HSD11B1
MoA: Gap junction modulator
SMILES: C[C@]12CC[C@@](C)(C[C@@H]1C1=CC(=O)[C@H]3[C@@]4(C)CC[C@H](O)C(C)(C)[C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(O)=O
InchiKey: MPDGHEJMBKOTSU-AOLSMHRZSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
121736 BRD-K80535353 HA1E 10 uM 24 h 0.29 1.19 0.42 0.0 0.0 0.0
129758 BRD-K80535353 A375 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129832 BRD-K80535353 HEK293 0.25 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.58
129873 BRD-K80535353 HELA 0.08 uM 24 h 0.28 1.18 0.39 -0.32 -1.09 0.82
129896 BRD-K80535353 HT29 0.01 uM 24 h -0.23 -0.96 0.1 0.0 0.0 0.0
129958 BRD-K80535353 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130002 BRD-K80535353 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 -0.21 -0.7 0.03
130043 BRD-K80535353 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130084 BRD-K80535353 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130115 BRD-K80535353 THP1 0.01 uM 24 h -0.29 -1.2 0.55 0.0 0.0 0.0
130160 BRD-K80535353 YAPC 0.74 uM 24 h -0.24 -0.99 0.13 -0.22 -0.75 0.06
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).