CMap Candidate Details

Structure:
CMap ID: C28049
Pert ID: BRD-K80700417
Compound Name: SGI-1776
Targets: PIM2; FLT3; PIM3; PIM1
MoA: Pim kinase inhibitor
SMILES: CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1
InchiKey: MHXGEROHKGDZGO-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
92953 BRD-K80700417 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92979 BRD-K80700417 CD34 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93032 BRD-K80700417 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93070 BRD-K80700417 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93117 BRD-K80700417 HELA 10 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
93156 BRD-K80700417 HEPG2 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.68
93205 BRD-K80700417 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93262 BRD-K80700417 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93305 BRD-K80700417 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93387 BRD-K80700417 NPC 3.33 uM 24 h 0.0 0.0 0.0 -0.3 -1.03 0.62
93438 BRD-K80700417 PC3 0.12 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.87
93506 BRD-K80700417 SKL 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93533 BRD-K80700417 THP1 3.33 uM 24 h -0.24 -0.99 0.13 0.0 0.0 0.0
117009 BRD-K80700417 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117125 BRD-K80700417 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117220 BRD-K80700417 HT29 10 uM 24 h 0.19 0.79 0.0 -0.25 -0.83 0.16
117259 BRD-K80700417 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126388 BRD-K80700417 A549 10 uM 24 h -0.22 -0.92 0.06 0.0 0.0 0.0
126560 BRD-K80700417 MDAMB231 10 uM 24 h -0.19 -0.8 0.0 0.24 0.84 0.12
126616 BRD-K80700417 YAPC 10 uM 24 h 0.0 0.0 0.0 0.34 1.19 1.03
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).