CMap Candidate Details

Structure:
CMap ID: C02809
Pert ID: BRD-K01292756
Compound Name: pimozide
Targets: DRD2; DRD3; HTR2A
MoA: Dopamine receptor antagonist
SMILES: Fc1ccc(cc1)C(CCCN1CCC(CC1)n1c2ccccc2[nH]c1=O)c1ccc(F)cc1
InchiKey: YVUQSNJEYSNKRX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3128 BRD-K01292756 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8893 BRD-K01292756 A375 10 uM 24 h 0.0 0.0 0.0 0.39 1.39 2.17
9162 BRD-K01292756 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9328 BRD-K01292756 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9634 BRD-K01292756 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10924 BRD-K01292756 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11383 BRD-K01292756 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.4 1.4 2.18
11688 BRD-K01292756 NCIH508 10 uM 6 h 0.29 1.21 0.45 0.36 1.29 1.49
11955 BRD-K01292756 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12239 BRD-K01292756 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12440 BRD-K01292756 PC3 10 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.51
13181 BRD-K01292756 U937 10 uM 6 h -0.27 -1.12 0.38 0.0 0.0 0.0
13436 BRD-K01292756 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44811 BRD-K01292756 ASC 10 uM 24 h 0.0 0.0 0.0 0.36 1.29 1.46
45127 BRD-K01292756 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45758 BRD-K01292756 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
46247 BRD-K01292756 PHH 10 uM 24 h -0.25 -1.03 0.2 -0.34 -1.16 1.11
46562 BRD-K01292756 SKB 10 uM 24 h -0.26 -1.06 0.26 0.0 0.0 0.0
90945 BRD-K01292756 HUH7 6.66 uM 72 h 0.0 0.0 0.0 0.27 0.95 0.31
98738 BRD-K01292756 NPC 10 uM 24 h 0.0 0.0 0.0 0.33 1.15 0.9
98856 BRD-K01292756 NEU 10 uM 24 h 0.2 0.85 0.0 0.0 0.0 0.0
99958 BRD-K01292756 U2OS 10 uM 6 h 0.0 0.0 0.0 0.29 1.01 0.45
122859 BRD-K01292756 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122890 BRD-K01292756 HEK293 3.33 uM 24 h 0.25 1.06 0.18 -0.3 -1.01 0.56
123015 BRD-K01292756 JURKAT 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123061 BRD-K01292756 MCF10A 0.04 uM 24 h -0.15 -0.63 0.0 0.0 0.0 0.0
123104 BRD-K01292756 MDAMB231 1.11 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.39
123176 BRD-K01292756 THP1 0.37 uM 24 h 0.25 1.05 0.17 -0.3 -1.02 0.61
131302 BRD-K01292756 HELA 0.01 uM 24 h 0.2 0.84 0.0 -0.2 -0.67 0.01
131352 BRD-K01292756 HUVEC 0.01 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.03
131491 BRD-K01292756 YAPC 0.08 uM 24 h 0.21 0.88 0.02 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).