CMap Candidate Details

Structure:
CMap ID: C28152
Pert ID: BRD-K81029756
Compound Name: diltiazem
Targets: CACNA1C
MoA: Calcium channel blocker
SMILES: COc1ccc(cc1)[C@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@H]2OC(=O)C
InchiKey: HSUGRBWQSSZJOP-LEWJYISDSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1782 BRD-K81029756 HA1E 10 uM 6 h -0.28 -1.16 0.45 0.0 0.0 0.0
1980 BRD-K81029756 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2426 BRD-K81029756 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2780 BRD-K81029756 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41847 BRD-K81029756 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41981 BRD-K81029756 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42790 BRD-K81029756 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43083 BRD-K81029756 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43238 BRD-K81029756 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.32
43655 BRD-K81029756 NPC 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.82
43958 BRD-K81029756 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44210 BRD-K81029756 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).