CMap Candidate Details

Structure:
CMap ID: C28196
Pert ID: BRD-K81169441
Compound Name: cerivastatin
Targets: HMGCR
MoA: HMGCR inhibitor
SMILES: COCc1c(nc(C(C)C)c(/C=C/[C@@H](O)C[C@@H](O)CC(=O)O)c1c2ccc(F)cc2)C(C)C
InchiKey: SEERZIQQUAZTOL-ANMDKAQQSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24481 BRD-K81169441 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24610 BRD-K81169441 A549 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.26
24809 BRD-K81169441 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24946 BRD-K81169441 HT29 10 uM 6 h 0.0 0.0 0.0 -0.35 -1.17 1.13
25044 BRD-K81169441 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
25190 BRD-K81169441 PC3 10 uM 24 h 0.2 0.83 0.0 0.0 0.0 0.0
25423 BRD-K81169441 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90927 BRD-K81169441 HUH7 6.66 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).