CMap Candidate Details

Structure:
CMap ID: C28208
Pert ID: BRD-K81209512
Compound Name: AG-494
Targets: EGFR
MoA: EGFR inhibitor; Tyrosine kinase inhibitor
SMILES: Oc1ccc(C=C(C#N)C(=O)Nc2ccccc2)cc1O
InchiKey: HKHOVJYOELRGMV-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1635 BRD-K81209512 HA1E 10 uM 24 h -0.28 -1.16 0.48 0.0 0.0 0.0
1982 BRD-K81209512 HCC515 10 uM 24 h 0.18 0.77 0.0 0.27 0.96 0.33
2428 BRD-K81209512 PC3 10 uM 6 h -0.24 -1.02 0.17 0.31 1.09 0.67
2501 BRD-K81209512 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39190 BRD-K81209512 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39498 BRD-K81209512 A549 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.85 0.2
39780 BRD-K81209512 ASC 10 uM 24 h -0.2 -0.83 0.0 0.0 0.0 0.0
40073 BRD-K81209512 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40337 BRD-K81209512 HT29 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.04 0.67
40513 BRD-K81209512 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
40880 BRD-K81209512 NEU 10 uM 24 h -0.19 -0.81 0.0 -0.3 -1.01 0.58
41199 BRD-K81209512 NPC 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.15
41538 BRD-K81209512 SKB 10 uM 24 h -0.21 -0.87 0.02 -0.33 -1.11 0.91
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).