CMap Candidate Details

Structure:
CMap ID: C28353
Pert ID: BRD-K81694556
Compound Name: VTP-27999
Targets: REN
MoA: Renin inhibitor
SMILES: CN[C@H](CNC(=O)N1CCC[C@H](C1)[C@@H](OCCNC(=O)OC)c1cccc(Cl)c1)C[C@H]1CCCOC1
InchiKey: NXWASIVXQMMPLM-ZXMXYHOLSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125961 BRD-K81694556 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125979 BRD-K81694556 A549 10 uM 24 h 0.22 0.91 0.04 0.0 0.0 0.0
126117 BRD-K81694556 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.27 0.94 0.29
126170 BRD-K81694556 MCF10A 0.04 uM 24 h 0.21 0.86 0.01 -0.24 -0.82 0.15
126257 BRD-K81694556 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126289 BRD-K81694556 THP1 0.04 uM 24 h -0.23 -0.98 0.12 0.0 0.0 0.0
126335 BRD-K81694556 YAPC 1.11 uM 24 h 0.0 0.0 0.0 -0.41 -1.39 2.02
134061 BRD-K81694556 HA1E 0.01 uM 24 h -0.27 -1.12 0.38 0.0 0.0 0.0
134091 BRD-K81694556 HEK293 0.08 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.62
134142 BRD-K81694556 HELA 0.08 uM 24 h 0.19 0.81 0.0 0.0 0.0 0.0
134176 BRD-K81694556 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134204 BRD-K81694556 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134222 BRD-K81694556 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134251 BRD-K81694556 MDAMB231 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).