CMap Candidate Details

Structure:
CMap ID: C28395
Pert ID: BRD-K81839095
Compound Name: estrone
Targets: ESR1
MoA: Estrogen receptor agonist
SMILES: C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2=O
InchiKey: DNXHEGUUPJUMQT-CBZIJGRNSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4145 BRD-K81839095 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5129 BRD-K81839095 VCAP 10 uM 6 h -0.19 -0.81 0.0 -0.28 -0.94 0.36
37745 BRD-K81839095 ASC 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.27 1.44
37948 BRD-K81839095 HEPG2 10 uM 6 h -0.21 -0.87 0.02 0.0 0.0 0.0
38109 BRD-K81839095 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38561 BRD-K81839095 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39011 BRD-K81839095 SKB 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.16
53258 BRD-K81839095 MCF10A 12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91283 BRD-K81839095 HUH7 12.5 uM 72 h 0.33 1.36 0.97 -0.34 -1.15 1.08
98938 BRD-K81839095 NEU 10 uM 24 h 0.0 0.0 0.0 -0.4 -1.33 1.83
119188 BRD-K81839095 A375 10 uM 24 h 0.19 0.77 0.0 0.0 0.0 0.0
119217 BRD-K81839095 A549 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119276 BRD-K81839095 HCC515 10 uM 24 h 0.23 0.95 0.07 0.0 0.0 0.0
119354 BRD-K81839095 MCF??7.00 10 uM 24 h 0.29 1.21 0.46 -0.35 -1.19 1.16
119379 BRD-K81839095 PC3 0.12 uM 24 h -0.21 -0.86 0.02 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).