CMap Candidate Details

Structure:
CMap ID: C28460
Pert ID: BRD-K82036761
Compound Name: sertraline
Targets: SLC6A4
MoA: Serotonin receptor antagonist
SMILES: CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12
InchiKey: VGKDLMBJGBXTGI-SJCJKPOMSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1467 BRD-K82036761 NPC 6.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5367 BRD-K82036761 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5804 BRD-K82036761 HCC515 10 uM 6 h 0.0 0.0 0.0 0.32 1.14 0.86
5958 BRD-K82036761 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6057 BRD-K82036761 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6219 BRD-K82036761 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6593 BRD-K82036761 VCAP 10 uM 6 h 0.0 0.0 0.0 0.29 1.04 0.54
25046 BRD-K82036761 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.34 1.2 1.07
37192 BRD-K82036761 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37311 BRD-K82036761 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37746 BRD-K82036761 ASC 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.73 0.05
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).