CMap Candidate Details

Structure:
CMap ID: C28477
Pert ID: BRD-K82091397
Compound Name: SB-239063
Targets: MAPK14; MAPK11
MoA: P38 MAPK inhibitor
SMILES: COc1nccc(n1)-c1c(ncn1[C@H]1CC[C@H](O)CC1)-c1ccc(F)cc1
InchiKey: ZQUSFAUAYSEREK-WKILWMFISA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33936 BRD-K82091397 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34188 BRD-K82091397 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34429 BRD-K82091397 HA1E 10 uM 6 h -0.24 -1.01 0.16 0.23 0.8 0.08
34694 BRD-K82091397 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34971 BRD-K82091397 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35211 BRD-K82091397 HT29 10 uM 6 h 0.0 0.0 0.0 0.29 1.04 0.56
36107 BRD-K82091397 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36360 BRD-K82091397 PHH 10 uM 24 h -0.23 -0.96 0.09 -0.27 -0.91 0.3
36658 BRD-K82091397 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37008 BRD-K82091397 VCAP 10 uM 6 h 0.26 1.08 0.22 0.25 0.89 0.2
91524 BRD-K82091397 BT20 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91585 BRD-K82091397 HS578T 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91624 BRD-K82091397 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91666 BRD-K82091397 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
91698 BRD-K82091397 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91736 BRD-K82091397 SKBR3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97285 BRD-K82091397 HAP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97345 BRD-K82091397 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).