CMap Candidate Details

Structure:
CMap ID: C28486
Pert ID: BRD-K82109576
Compound Name: vincristine
Targets: TUBB
MoA: Tubulin inhibitor
SMILES: CC[C@]1(O)C[C@@H]2CN(C1)CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)[C@@H]7[C@@]86CCN9CC=C[C@](CC)([C@H]98)[C@@H](OC(=O)C)[C@]7(O)C(=O)OC
InchiKey: OGWKCGZFUXNPDA-CFWMRBGOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24483 BRD-K82109576 A375 10 uM 6 h 0.0 0.0 0.0 -0.37 -1.26 1.36
24612 BRD-K82109576 A549 10 uM 24 h -0.25 -1.06 0.25 -0.29 -0.99 0.5
24811 BRD-K82109576 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.92 0.31
24948 BRD-K82109576 HT29 10 uM 6 h 0.2 0.82 0.0 0.0 0.0 0.0
25109 BRD-K82109576 MCF??7.00 10 uM 6 h 0.19 0.81 0.0 -0.22 -0.74 0.06
25191 BRD-K82109576 PC3 10 uM 24 h -0.25 -1.04 0.21 0.0 0.0 0.0
25426 BRD-K82109576 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).