CMap Candidate Details

Structure:
CMap ID: C28502
Pert ID: BRD-K82147103
Compound Name: lofepramine
Targets: SLC6A2; SLC6A4
MoA: Serotonin reuptake inhibitor; Norepinephrine reuptake inhibitor
SMILES: CN(CCCN1c2ccccc2CCc2ccccc12)CC(=O)c1ccc(Cl)cc1
InchiKey: SAPNXPWPAUFAJU-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24485 BRD-K82147103 A375 10 uM 6 h 0.0 0.0 0.0 0.25 0.87 0.17
24695 BRD-K82147103 A549 10 uM 6 h 0.0 0.0 0.0 0.33 1.16 0.91
24950 BRD-K82147103 HT29 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.04 0.65
25047 BRD-K82147103 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.34
25193 BRD-K82147103 PC3 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.48
25428 BRD-K82147103 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).