CMap Candidate Details

Structure:
CMap ID: C02853
Pert ID: BRD-K01436366
Compound Name: XMD-1150
Targets: LRRK2
MoA: Leucine rich repeat kinase inhibitor
SMILES: COc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccccc3N(C)c2n1)C(=O)N1CCC(CC1)N1CCN(C)CC1
InchiKey: IWMCPJZTADUIFX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
490 BRD-K01436366 BJAB 10 uM 24 h 0.28 1.17 0.36 -0.21 -0.7 0.03
553 BRD-K01436366 HBL1 10 uM 4 h -0.26 -1.08 0.29 -0.41 -1.39 2.02
596 BRD-K01436366 K562 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
628 BRD-K01436366 KMS34 2.5 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.95
673 BRD-K01436366 MINO 2.5 uM 24 h 0.23 0.97 0.08 -0.33 -1.1 0.87
721 BRD-K01436366 NALM6 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.09
757 BRD-K01436366 OCILY19 2.5 uM 24 h 0.0 0.0 0.0 -0.44 -1.49 15.35
806 BRD-K01436366 OCILY3 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.7
862 BRD-K01436366 SKMEL5 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.17
907 BRD-K01436366 THP1 10 uM 24 h 0.0 0.0 0.0 -0.18 -0.61 0.0
936 BRD-K01436366 TMD8 2.5 uM 24 h 0.0 0.0 0.0 -0.44 -1.46 15.35
34023 BRD-K01436366 ASC 10 uM 24 h -0.23 -0.94 0.08 0.0 0.0 0.0
34538 BRD-K01436366 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.9 0.29
34806 BRD-K01436366 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35528 BRD-K01436366 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35713 BRD-K01436366 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36179 BRD-K01436366 PHH 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
36473 BRD-K01436366 SKB 10 uM 24 h 0.24 1.02 0.12 0.0 0.0 0.0
36940 BRD-K01436366 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.39 -1.31 1.71
91502 BRD-K01436366 BT20 10 uM 24 h 0.31 1.28 0.61 0.0 0.0 0.0
91681 BRD-K01436366 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92447 BRD-K01436366 A549 10 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.72
92517 BRD-K01436366 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92572 BRD-K01436366 HME1 1.11 uM 3 h 0.0 0.0 0.0 -0.32 -1.06 0.75
92615 BRD-K01436366 HS578T 10 uM 3 h 0.0 0.0 0.0 -0.42 -1.42 2.5
92644 BRD-K01436366 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92688 BRD-K01436366 LNCAP 10 uM 24 h -0.17 -0.69 0.0 0.0 0.0 0.0
92754 BRD-K01436366 MCF10A 0.12 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92819 BRD-K01436366 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92842 BRD-K01436366 SKBR3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96616 BRD-K01436366 A375 10 uM 24 h 0.19 0.78 0.0 0.0 0.0 0.0
97508 BRD-K01436366 MCF??7.00 20 uM 24 h 0.0 0.0 0.0 -0.39 -1.33 1.71
97615 BRD-K01436366 NKDBA 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).