CMap Candidate Details

Structure:
CMap ID: C28537
Pert ID: BRD-K82236179
Compound Name: dicoumarol
Targets: NQO1; VKORC1
MoA: NADPH inhibitor
SMILES: Oc1c(Cc2c(O)c3ccccc3oc2=O)c(=O)oc2ccccc12
InchiKey: DOBMPNYZJYQDGZ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125577 BRD-K82236179 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125628 BRD-K82236179 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125726 BRD-K82236179 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.28 1.01 0.44
125800 BRD-K82236179 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.96
125892 BRD-K82236179 THP1 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.76 0.07
125925 BRD-K82236179 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133662 BRD-K82236179 A549 0.25 uM 24 h 0.0 0.0 0.0 0.28 1.0 0.43
133729 BRD-K82236179 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133760 BRD-K82236179 HELA 0.74 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.58
133794 BRD-K82236179 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133822 BRD-K82236179 JURKAT 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133880 BRD-K82236179 MCF??7.00 0.03 uM 24 h -0.25 -1.03 0.19 0.0 0.0 0.0
133909 BRD-K82236179 MDAMB231 0.01 uM 24 h 0.28 1.17 0.38 0.0 0.0 0.0
133939 BRD-K82236179 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).