CMap Candidate Details

Structure:
CMap ID: C28538
Pert ID: BRD-K82244583
Compound Name: MEK-162
Targets: --
MoA: --
SMILES: Cn1cnc2c(F)c(Nc3ccc(Br)cc3F)c(cc12)C(=O)NOCCO
InchiKey: ACWZRVQXLIRSDF-UHFFFAOYSA-N
Compound Aliases: binimetinib

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126029 BRD-K82244583 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.25 0.87 0.17
126076 BRD-K82244583 HUVEC 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.3 1.58
126121 BRD-K82244583 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126174 BRD-K82244583 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126259 BRD-K82244583 PC3 0.37 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.48
126293 BRD-K82244583 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126338 BRD-K82244583 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.36 1.28 1.37
134003 BRD-K82244583 A375 2.22 uM 24 h 0.0 0.0 0.0 0.25 0.87 0.17
134034 BRD-K82244583 A549 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134063 BRD-K82244583 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.35 1.25 1.29
134095 BRD-K82244583 HEK293 0.08 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.63
134179 BRD-K82244583 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134225 BRD-K82244583 MCF??7.00 0.74 uM 24 h -0.26 -1.07 0.27 0.33 1.17 0.93
134253 BRD-K82244583 MDAMB231 2.22 uM 24 h 0.18 0.76 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).