CMap Candidate Details

Structure:
CMap ID: C28685
Pert ID: BRD-K82746043
Compound Name: navitoclax
Targets: BCL2; BCL2L1; BCL2L2
MoA: BCL inhibitor
SMILES: CC1(C)CCC(=C(CN2CCN(CC2)c2ccc(cc2)C(=O)NS(=O)(=O)c2ccc(N[C@H](CCN3CCOCC3)CSc3ccccc3)c(c2)S(=O)(=O)C(F)(F)F)C1)c1ccc(Cl)cc1
InchiKey: JLYAXFNOILIKPP-KXQOOQHDSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9522 BRD-K82746043 AGS 10 uM 6 h 0.25 1.04 0.14 0.0 0.0 0.0
9827 BRD-K82746043 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11589 BRD-K82746043 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11851 BRD-K82746043 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12147 BRD-K82746043 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13371 BRD-K82746043 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13689 BRD-K82746043 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.22 -0.75 0.06
95497 BRD-K82746043 A549 10 uM 48 h 0.0 0.0 0.0 -0.34 -1.14 1.01
95653 BRD-K82746043 U2OS 10 uM 48 h 0.0 0.0 0.0 -0.34 -1.15 1.07
117463 BRD-K82746043 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117510 BRD-K82746043 HEPG2 10 uM 24 h -0.28 -1.15 0.44 -0.31 -1.04 0.67
117554 BRD-K82746043 HT29 3.33 uM 24 h -0.36 -1.49 1.43 0.0 0.0 0.0
126411 BRD-K82746043 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126462 BRD-K82746043 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
126485 BRD-K82746043 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126566 BRD-K82746043 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126587 BRD-K82746043 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126617 BRD-K82746043 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134364 BRD-K82746043 A375 2.22 uM 24 h 0.0 0.0 0.0 0.2 0.7 0.02
134529 BRD-K82746043 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134554 BRD-K82746043 MCF10A 0.01 uM 24 h -0.22 -0.9 0.04 -0.28 -0.94 0.37
134581 BRD-K82746043 MCF??7.00 0.01 uM 24 h 0.23 0.96 0.08 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).