CMap Candidate Details

Structure:
CMap ID: C28709
Pert ID: BRD-K82795137
Compound Name: loratadine
Targets: HRH1
MoA: Histamine receptor antagonist
SMILES: CCOC(=O)N1CCC(CC1)=C1c2ccc(Cl)cc2CCc2cccnc12
InchiKey: JCCNYMKQOSZNPW-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25429 BRD-K82795137 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.12
91476 BRD-K82795137 HUH7 8 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
125964 BRD-K82795137 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125983 BRD-K82795137 A549 10 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
126004 BRD-K82795137 HA1E 10 uM 24 h -0.21 -0.86 0.02 -0.21 -0.71 0.04
126052 BRD-K82795137 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126127 BRD-K82795137 JURKAT 10 uM 24 h -0.29 -1.21 0.57 -0.35 -1.18 1.14
126180 BRD-K82795137 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126219 BRD-K82795137 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126263 BRD-K82795137 PC3 10 uM 24 h 0.24 1.01 0.12 0.32 1.12 0.77
126299 BRD-K82795137 THP1 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.05
134101 BRD-K82795137 HEK293 0.74 uM 24 h 0.26 1.08 0.21 -0.35 -1.18 1.14
134148 BRD-K82795137 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134206 BRD-K82795137 HUVEC 0.01 uM 24 h 0.24 0.99 0.1 0.0 0.0 0.0
134258 BRD-K82795137 MDAMB231 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134313 BRD-K82795137 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).