CMap Candidate Details

Structure:
CMap ID: C28717
Pert ID: BRD-K82823076
Compound Name: Ro-15-4513
Targets: GABRA1; GABRA2; GABRA3; GABRA5
MoA: GABA benzodiazepine site receptor inverse agonist
SMILES: CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=[N+]=[N-]
InchiKey: CFSOJZTUTOQNIA-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3058 BRD-K82823076 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.98 0.49
3269 BRD-K82823076 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.16 1.11
3644 BRD-K82823076 PC3 10 uM 6 h 0.0 0.0 0.0 0.3 1.07 0.63
3982 BRD-K82823076 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39198 BRD-K82823076 A375 10 uM 6 h -0.19 -0.8 0.0 0.0 0.0 0.0
39502 BRD-K82823076 A549 10 uM 6 h 0.0 0.0 0.0 0.29 1.01 0.45
39787 BRD-K82823076 ASC 10 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
40079 BRD-K82823076 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.86 0.2
40344 BRD-K82823076 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40515 BRD-K82823076 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40886 BRD-K82823076 NEU 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.29 1.52
41207 BRD-K82823076 NPC 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
41546 BRD-K82823076 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).