CMap Candidate Details

Structure:
CMap ID: C28727
Pert ID: BRD-K82846253
Compound Name: repaglinide
Targets: KCNJ11; ABCC8
MoA: Insulin secretagogue
SMILES: CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(O)=O
InchiKey: FAEKWTJYAYMJKF-QHCPKHFHSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25048 BRD-K82846253 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25536 BRD-K82846253 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
52340 BRD-K82846253 PC3 10 uM 24 h 0.0 0.0 0.0 0.4 1.42 2.19
96291 BRD-K82846253 U2OS 10 uM 24 h -0.29 -1.21 0.58 0.0 0.0 0.0
125985 BRD-K82846253 A549 0.04 uM 24 h -0.23 -0.96 0.09 -0.27 -0.91 0.29
126084 BRD-K82846253 HUVEC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126130 BRD-K82846253 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.86
126183 BRD-K82846253 MCF10A 0.125 uM 24 h 0.25 1.05 0.17 0.0 0.0 0.0
126239 BRD-K82846253 MDAMB231 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126301 BRD-K82846253 THP1 0.125 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
126342 BRD-K82846253 YAPC 1.11 uM 24 h 0.24 0.99 0.09 0.0 0.0 0.0
134009 BRD-K82846253 A375 0.08 uM 24 h -0.29 -1.19 0.53 0.24 0.86 0.16
134067 BRD-K82846253 HA1E 0.74 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.42
134104 BRD-K82846253 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134150 BRD-K82846253 HELA 0.03 uM 24 h 0.32 1.33 0.84 0.0 0.0 0.0
134182 BRD-K82846253 HT29 0.01 uM 24 h 0.29 1.22 0.48 -0.27 -0.92 0.33
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).