CMap Candidate Details

Structure:
CMap ID: C28757
Pert ID: BRD-K82928847
Compound Name: ACY-1215
Targets: HDAC6
MoA: HDAC inhibitor
SMILES: ONC(=O)CCCCCCNC(=O)c1cnc(nc1)N(c1ccccc1)c1ccccc1
InchiKey: QGZYDVAGYRLSKP-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
93647 BRD-K82928847 ASC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93705 BRD-K82928847 CD34 10 uM 24 h 0.24 1.0 0.11 -0.25 -0.84 0.18
93787 BRD-K82928847 HCC515 1.11 uM 24 h 0.0 0.0 0.0 0.21 0.76 0.05
93920 BRD-K82928847 HEPG2 1.11 uM 24 h -0.26 -1.06 0.26 0.0 0.0 0.0
94097 BRD-K82928847 NEU 0.37 uM 24 h 0.27 1.14 0.32 0.0 0.0 0.0
94135 BRD-K82928847 NPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94230 BRD-K82928847 SHSY5Y 3.33 uM 24 h -0.29 -1.22 0.61 0.0 0.0 0.0
94281 BRD-K82928847 SKL 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
94376 BRD-K82928847 YAPC 10 uM 24 h 0.22 0.91 0.04 0.0 0.0 0.0
97255 BRD-K82928847 HAP1 0.66 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
125579 BRD-K82928847 A375 10 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
125612 BRD-K82928847 A549 3.33 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.57
125649 BRD-K82928847 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.4 -1.34 1.85
125730 BRD-K82928847 HUVEC 3.33 uM 24 h 0.23 0.94 0.06 -0.27 -0.89 0.27
125776 BRD-K82928847 JURKAT 3.33 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
125826 BRD-K82928847 MCF??7.00 3.33 uM 24 h -0.25 -1.02 0.19 0.0 0.0 0.0
125872 BRD-K82928847 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133696 BRD-K82928847 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133762 BRD-K82928847 HELA 0.74 uM 24 h 0.21 0.88 0.02 0.0 0.0 0.0
133795 BRD-K82928847 HT29 2.22 uM 24 h -0.24 -1.01 0.16 -0.24 -0.79 0.11
133854 BRD-K82928847 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
133912 BRD-K82928847 MDAMB231 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133976 BRD-K82928847 THP1 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).